Articles - publications
Coeur et système adrénergique en hypoxie / Transduction du signal dans les récepteurs cardiaques/circulation
Leon-VelardeF., Richalet J-P., Chavez J-C., Kacimi R., Rivera-Chira M., Palacios J-A., Clark D. Inter and intra-species-related differences in the regulation of the cardiac autonomic system. Comparative Biochemistry and Physiology in press 1998.Gonzalez N. C., Clancy R. L., Moue Y., Richalet J-P. Increasing maximal heart rate increases maximal O2 uptake in rats acclimatized to simulated altitude. J. Appl. Physiol. 84(1): 164-168, 1998
Leon-Velarde F., Richalet J-P., Chavez J-C., Kacimi R. Rivera-Chira M., Palacios J-A., Clark D. Hypoxia and normoxia induced reversibility of autonomic control in Andean guinea heart. J. Appl. Physiol. 81(5) : 2229-2234, 1996.
Court-Payen M., Ter Minassian A., Olsen N. V., Kanstrup I-L., Dubray C., Richalet J-P. The effect of Isradipine in acute altitude hypoxia on cerebral, ranal, and splanchnic blood flow evaluated by Doppler measurements. International Journal of Angiology 4: 212-217, 1995
Kacimi R., Moalic J.M., Aldashev A., Vatner D.E., Richalet J.-P. and B. Crozatier. Differential regulation of G protein expression in rat hearts exposed to chronic hypoxia. Am. J. Physiol. (Heart and Circ Physiol 38), H1865-1873, 1995
Dugas L, Dubray C, Herry JP, Olsen NV, Court-Payen M, Hansen JM, Robach P, Ter-Minassian A, Richalet JP. Effets cardiovasculaires d’un bloqueur calcique en hypoxie d’altitude. La Presse Médicale 24: 763-768,1995
Antezana A.-M., Kacimi R., Le Trong J.-L., Marchal M., Abousahl I., Dubray C. and J.-P. Richalet. Adrenergic status of humans during prolonged exposure to the altitude of 6542m. J. Appl. Physiol. 76(3): 1055-1059, 1994.
Kacimi R., Richalet J.-P., and B. Crozatier. Hypoxia-induced differential modulation of adenosinergic and muscarinic receptors in rat heart. J Appl. Physiol. 75(3): 1123-1128, 1993.
Kacimi R., Richalet J.-P., Corsin A., Abousahl I. and B. Crozatier. Hypoxia induced downregulation of ß-adrenergic receptors in rat heart. J. Appl. Physiol. 73(4):1377-1382, 1992.
Richalet J.-P. , R. Kacimi and A.-M. Antezana. The control of chronotropic function in hypobaric hypoxia. Int. J. Sports Med. 13:S22-S24, 1992.
Pilardeau P., J.-P. Richalet, P. Bouissou, J. Vaysse, P. Larmignat, A. Boom. Saliva flow and composition in humans exposed to acute altitude hypoxia. Eur. J. Appl. Physiol. 59:450-453, 1990
Richalet J-P. The heart and adrenergic system in hypoxia. Editors Sutton J. R., Coates G., Remmers J. E. Hypoxia. The adaptations 231-240, 1990
Richalet J.-P., C. Rathat, A. Kéromès, P. Larmignat. Effets de l'atropine sur la réponse adrénergique à l'exercice en hypoxie d'altitude (4350m). Science et sports. 5: 77-82, 1990.
Richalet J.-P., P. Merlet, M. Bourguignon, J.-L. Le Trong, A. Kéromès, C. Rathat, B Jouve, M. A. Hot, A. Castaigne, A. Syrota. MIBG scintigraphic assessment of cardiac adrenergic activity in response to altitude hypoxia. J. Nucl. Med. 31:34-37, 1990.
Bouissou P., J.-P. Richalet, F.X. Galen, M. Lartigue, P. Larmignat, F. Devaux, C. Dubray and A. Kéromès. Effect of ß-adrenoceptor blockade on renin-aldosterone and a-ANF during exercise at altitude. J. Appl. Physiol. 67(1):141-146, 1989.
Bouissou P., Galen F-X., Richalet J-P., Lartigue M., Devaux F., Dubray C., Atlan G. Effects of propranodol and pindolol on plasma ANP levels in humans at rest and during exercise. Am. J. Physiol. 257 (regulatory Integrative Comp. Physiol. 26): R259-R264, 1989.
Richalet J.-P., J.-L. Le-Trong, C. Rathat, P. Merlet, P. Bouissou, A. Kéromès, P. Veyrac. Reversal of hypoxia-induced decrease in human cardiac response to isoproterenol infusion. J. Appl. Physiol. 67(2):523-527, 1989.
Bouissou P., J.-P. Richalet, C. Dubray, M. Lartigue, J.-C. Aldigier, G. Habrioux et F.X. Galen. Effet du blocage des récepteurs ß adrénergiques sur le facteur natriurétique auriculaire, l'aldostérone et l'activité rénine plasmatique, au cours de l'exercice physique. Arch. Mal. Coeur 82:1241-1243, 1989
Richalet J.-P., H. Mehdioui, C. Rathat, P. Vignon, A. Kéromès, J.-P. Herry, C. Sabatier, M. Tanche, F. Lhoste. Acute hypoxia decreases cardiac response to catecholamines in exercising humans. Int. J. Sports Med. 9:157-162, 1988.
Richalet J.-P., P. Larmignat, C. Rathat, A. Kéromès, P. Baud and F. Lhoste. Decreased human cardiac response to isoproterenol infusion in acute and chronic hypoxia. J. Appl. Physiol. 65(5):1957-1961, 1988.
Pecquet C., Richalet J-P., Kayser B., Larmignat P., Keromes A. Utilisation de la photopléthysmographie et de la vzlocimétrie laser Doppler dans l’exploration de la vasomotricité cutanée en haute altitude. Presse Méd. 17: 1128-1131, 1988.
Pathologie d’altitude / Mal des Montagnes / Physiopathologie / Moyens thérapeutiques / Pré-acclimatation
Poulsen T. D., Klausen T., Richalet J-P., Kanstrup I-L., Fogh-Andersen N., Olsen N. V. Plasma volume in acute hypoxia : comparison of a carbon monoxide rebreathing method and dye dilution with Evans’ blue. Eur. J. Appl. Physiol. 77: 457-61, 1998.Klausen T., Olsen N. V., Poulsen T. D., Richalet J-P., Pedersen B. K. Hypoxemia increases serum interleukin-6 in humans. Eur. J. Appl. Physiol. 76 : 480-482, 1997
Westerterp K. R., Robach P., Wouters L., Richalet J-P. Water balance and acute mountain sickness before and after arrival at high altitude of 4.350m. J. Appl. Physiol. 80(6) : 1968-1972, 1996.
Richalet J.-P. High-altitude pulmonary oedema. Still a place for controversy? Thorax 50: 923-929, 1995.
Dubois C., Herry J-P., Kayser B. Portable hyperbaric medicine, some history. Journal of Wilderness Medicine 5: 190-198, 1994.
Hansen J. M., Olsen N. V., Feldt-Rasmussen B., Kanstrup I.-L., Déchaux M., Dubray C., and J.-P. Richalet. Albuminuria and overall capillary permeability of albuminin acute altitude hypoxia. J. Appl. Physiol. 76 (5): 1922-1927, 1994.
Verschurr H.P., Richalet J.-P., Rathat C., Frachet B. Mal aigu des montagnes et crise de Ménière. Ann. Otolaryngol. Chir. Cervicofac. 110: 296-298, 1993.
Rathat C., Richalet J-P., Larmignat P., Herry J-P. Letters to the editors. Neck irradiation by cobalt therapy and susceptibility to acute mountain sickness. Journal of Wilderness Medicine. 4: 231-232, 1993.
Richalet J-P., Bittel J., Herry J-P., Savourey G., Le Trong J-P., Auvert J-F., Janin C. Use of a hypobaric chamber for pre-acclimatization before climbing mount Everest. Int. J. Sports Med. 13: S216-S220, 1992.
Richalet J.-P., Hornych A., Rathat C., Aumont J., Larmignat P. and P. Rémy. Plasma prostaglandins, leukotrienes and thromboxane in acute high altitude hypoxia. Respiration Physiology 85: 205-215, 1991.
Richalet J.-P.. Acute mountain sickness: risk factors. In: "A Colour Atlas of Mountain Medicine", J. Vallotton and F. Dubas eds, Wolfe Medical Pub. (London), pp 54-56, 212, 1991.
Richalet J-P., Bittel J., Herry J-P., Janin C., Savourey G., Le Trong J-L., Auvert J-F. Pre-aaclimatization to high altitude altitude in a hypobaric chamber : Everest Turbo. In : “Hypoxiaa and mountain medicine“ Suttton J.R., Coates G., Houston C. S. eds., Burlington, USA, 202-212, 1992.
Richalet J-P., Hornych A., Rathat C., Aumont J., Larmignat P., Rémy P. Plasma prostaglandins, leukotrienes and thromboxane in acute high altitude hypoxia. Respiration Physiology 85: 205-215, 1991.
Richalet J-P. Acute mountain sickness : risk factors. A colour atlas of mountain medicine. Edited by Vallotton J., Dubas F. WOLFE 1991.
Herry J.-P., Richalet J.-P., Rathat C., Benozillo J.-P. Le caisson hyperbare portable (CHP) dans le traitement de la pathologie de haute altitude. Urgences 9: 145-148, 1990.
Richalet J.-P., A. Kéromès, B. Dersch, F. Corizzi, H. Mehdioui, B. Pophillat, H. Chardonnet, F. Tassery, J.-P. Herry, C. Rathat, C. Chaduteau et B. Darnaud. Caractéristiques physiologiques des alpinistes de haute altitude. Science et Sport 3:89-108, 1988.
Richalet J.-P., Rathat C., Keromes A., Herry J-P., Larmignat P., Garnier M., Pilardeau P. Plasma volume, body weight and acute mountain sickness. The Lancet 608: 525, 1983
Exercice musculaire
Gonzalez N. C., Clancy R. L., Moue Y., Richalet J-P. Increasing maximal heart rate increases maximal O2 uptake in rats acclimatized to simulated altitude. J. Appl. Physiol. 84(1): 164-168, 1998Robach P., Biou D., Herry J-P., Deberne D., Letournel M., Vaysse J., Richalet J-P.
Recovery process after repeated supramaximal exercise at the altitude of 4.350m. J. Appl. Physiol. 82(6) : 1997.
Richalet J.-P., C. Rathat, A. Kéromès, P. Larmignat. Effets de l'atropine sur la réponse adrénergique à l'exercice en hypoxie d'altitude (4350m). Science et sports. 5: 77-82, 1990
Richalet J.-P., H. Mehdioui, C. Rathat, P. Vignon, A. Kéromès, J.-P. Herry, C. Sabatier, M. Tanche, F. Lhoste. Acute hypoxia decreases cardiac response to catecholamines in exercising humans. Int. J. Sports Med. 9:157-162, 1988.
Métabolisme énergétique / Fonction rénale / Erythropoïèse / Fonction endocrine
Hansen J. M., Kanstrup I. L., Richalet J-P., Olsens N. V. High altitude-induced albuminuria in normal man is enhanced by infusion of low-dose dopamine. Scand. J. Clin. Lab. Invest. 56 : 367-372; 1996.Klausen T., Poulsen T. D., Fogh-Andersen N., Richalet J-P., Nielsen O. J., Olsen N. V. Diurnal variations of serum erythropoietin at sea level and altitude. Eur. J. Appl. Physiol. 72 : 297-302, 1996.
Antezana A-M., Richalet J-P., Noriega I., Galrza M., Antezana G. Hormonal changes in normal and polycythemic high-altitude natives. J. Appl. Physiol. 79(3): 795-800, 1995.
Richalet J-P., Déchaux M., Bienvenu A., Souberbielle J-C., Antezana A-M., Cauchy E. Erythropoiesis and renal function at the altitude of 6.542m. Japanese Journal of Mountain Medicine 15 : 135-150, 1995.
Richalet J-P., Souberbielle J-C., Antezana A-M., Déchaux M;, Le Trong J-L., Bienvenu A., Daniel F., Blanchot C., Zittoun J. Am. J. Physiol. 266 (Regulatory Integrative Comp. Physiol. 35): R756-R764, 1994.
Westerterp K.S., Kayser B., Wouters L., Le Trong J-L., Richalet J-P. Energy balance at high altitude of 6.542m. J. Appl. Physiol. 77(2): 862-866, 1994.
Férézou J., Richalet J.-P., Sérougue C., Coste T., Wirquin E. and D. Mathé. Reduction of postprondial lipemia after acute exposure to high altitude hypoxia. Int. J. Sports Med. 14: 78-85,1993.
Olsen N.V., Hansen J.-M., Kanstrup I.-L., Richalet J.-P. and P.P. Leyssac. Renal hemodynamics, tubular function, and the response to low-dose dopamine during acute hypoxia in humans. J Appl. Physiol. 74(5): 2166-2173, 1993
Olsen N.V., Kanstrup I.-L., Richalet J.-P., Hansen J.M., Plazen G. and Galen F.X. Effects of acute hypoxia on renaland endocrine function at rest and during graded exercise in hydrated subjects. J. Appl. Physiol. 73(5): 2036-2043, 1992.
Guyard B., Richalet J.-P., Kacimi R., Berrou J.-P., Madelenat P. Altitude et grossesse. A propos d'un travail expérimental sur la rate gestante. J. Gynecol. Obstet. Biol. Reprod. 22: 605-610, 1993.
Ferezou J., J.-P. Richalet, T. Coste and C. Rathat. Changes in plasma lipids and lipoprotein cholesterol during a high altitude mountaineering expedition (4800m). Eur. J. Appl. Physiol. 57:740-745, 1988.
Neurophysiologie / Sommeil / Apnées du sommeil / Vision des couleurs
Bouchet P., Morlet D., Bertrand O., Fischer C., Richalet J-P. Effects of altitude hypoxia on middle latency auditory evoked potentiels in humans. Aviat. Space Environ. Med. 68 : 699-704, 1997.Richalet J.-P., V. Rutgers, P. Bouchet, Jean-Claude Rymer, A. Kéromès, G. Duval Arnould and C. Rathat. Diurnal variations of acute mountain sickness, coulour vision and plasma cortisol and ACTH at high altitude. Aviat. Space Envrion. Med. 60 :105-111, 1989.
Richalet J.-P., G. Duval-Arnould, B. Darnaud, A. Kéromès and V. Rutgers. Modification of colour vision in the green/red axis in acute and chronic hypoxia explored with a portable anomaloscope. Aviat. Space and Environ. Med. 59:620-623, 1988.
Goldenberg F., J.-P. Richalet, A. Kéromès, P. Veyrac, M. Jouhandin and A. Gisquet. Effects of loprazolam on high altitude insomnia and ventilation during sleep. In: "Sleep'86". Koella WP, Obal F, Schulz H and Visser P eds. Gustav Fischer Verlag Stuttgart, New-York, 340-342, 1988.
Goldenberg F., J.-P. Richalet, M. Jouhandin, A. Gisquet, A. Kéromès et P. Larmignat. Respiration périodique pendant le sommeil en altitude. Effets d'une benzodiazépine hypnotique, le Loprazolam. La Presse Médicale 17(10):471-474, 1988.
Goldenberg F., J.-P. Richalet, A. Kéromès, C. Rathat and B. Dantlo. Poor sleep induced by high altitude hypoxia. Effects of a thienodiazepine, Brotizolam. In "Sleep'84", Koella WP, Rüther E, Schulz H (eds), Gustav Fischer Verlag- Stuutgart, New York, p 316-318, 1985.
Revues générales
Richalet J-P. L’altitude : adaptation pulmonaire du sujet sain. Pathologie pulmonaire liée à l’altitude. Les actes du 2e congrès de pneumologie. Sport et maladies respiratoires. 443-447, 1998.
Richalet J-P. En pratique, coeur et altitude : les contre-indications. Réalités Cardiologiques 122: 23-24, 1998.
Richalet J-P. Coeur et séjour en altiutde. “Coeur et Sport 97“, Saint-Malo 28-29 novembre 1997, pages 23-30.
Richalet J-P. Oxygen sensors in the organism : examples of regulation under altitude hypoxia mammals. Comp. Biochem. Physiol. 118A(2): 9-14, 1997.
Richalet J-P., Leon-Velarde F. Pathophysiology of the altitude. Archivos de Medicina del Deporte XIV(60): 271-276, 1997
Richalet J-P. Physiopathologie de l’hypoxie d’altitude. Médecine & Hygiène 54 : 1062-66, 1996.
Richalet J-P., Larmignat P., Antezana A-M., Rathat C. Le mal aigu des montagnes et ses complications. La revue du Praticien 348 : 22-23, 1996.
Richalet J-P., Larmignat P., Antezana A-M., Rathat C. Séjour en haute montagne. Prévenir le mal des montagnes et ses complications. La revue du Praticien - médecine générale- 335 : 29-31, 1996.
Richalet J.-P. La physiologie de l'alpiniste. Pour la Science: Dossier hors serie, Paris, octobre 1994.
Richalet J.-P., Antezana A.M., Bienvenu A., Marchal M., Souberbiel J.-C., CauchyE., Le Trong J.-L., Déchaux M., Kacimi R., Bonaldi V., Westerterp K.R., Kayser B. and C. Dubray. Physiological factors of survival at extreme altitude. In "Hypoxia and Molecular Medicine", J.R. Sutton, G. Coates and C. Houston eds, Queen City Print., Burlington, USA. pp 235-251, 1993.
Richalet J.-P., C. Rathat. Poumon et Altitude. Encyclopédie Médico-Chirurgicale, 6-063-A-10, 1-7 , 1993.
Larmignat P.,Rathat C.,Herry J.-P. and J.-P. Richalet. Le Mal des Montagnes. La Gazette Médicale, 99 n°38 : 10-17, 1993.
Richalet J.-P., Rathat C., Herry J.-P., Larmignat P. La médecine et les montagnes. L'Observatoire Vallot, lieu de recherche privilégié. Urgences 9: 15-19, 1990.
Richalet J-P. Le mal des Montagnes frappe les Alpes. La recherche 223: 928-929, 1990
Herry J.-P., J.-P. Richalet, C. Rathat, J. Foray. Aspects matériels et techniques de la médecine de haute altitude. Science et Sport 3: 147-156, 1988.
Richalet J-P. L’adaptation à l’altitude. La recherche 18: 1482-1492, 1987.