Articles - publications
Morel O-E, Buvry A, Le
Corvoisier P, Tual L, Favret F, Léon-Velarde F, Crozatier
B, Richalet J-P. Effects of nifedipine-induced pulmonary
vasodilatation on cardiac receptors and protein kinase C
isoforms in the chronically hypoxic rat. Pflugers Arch.
Eur. J. Physiol. 446 : 356-364, 2003
Richalet J-P. Facteurs limitants de la performance en
haute altitude : opération Everest III,
Comex’97. Science et Sports 18 : 11-15, 2003.
Bouassida A, Zaouali M, Latiri I, Zelleg D, Ben Mdella S,
Richalet J-P, Tabka Z. Cinétique du cortisol et de
l’hormone de croissance plasmatiques lors de deux
épreuves sous-maximales avec et sans récupération.
Science et Sports 18 : 20-22, 2003
Favret F, Henderson KK, Richalet J-P, Gonzalez NC.
Effects of exercise training on acclimatization to
hypoxia: systemic O2 transport during maximal
exercise. J Appl Physiol. 95:1531-1541, 2003
Richalet J-P. Oxygène et physiologie dans les milieux
extrêmes: un modèle et ses applications. Ann Biol Clin
61: 203-205, 2003
Trabelsi Y, Ben Saad H, Tabka Z, Gharbi N, Bouchez Buvry
A, Richalet J-P, Guenard H. Spirometric reference values
in Tunisian children. Respiration 71: 511-518, 2004
Bouassida A, Zelleg D, Zaouali M, Gharbi N, Fekih Y,
Richalet J-P, Tabka Z. Effets d’un exercice
supra-maximal sur les concentrations de la leptine
plasmatique. Science et Sports 19: 136-138, 2004
Cornolo J, Mollard P, Brugniaux JV, Robach P, Richalet
J-P. Autonomic control of the cardiovascular system
during acclimatization to high altitude: effects of
sildenafil. J Appl Physiol 97: 935-940, 2004
Robach P, Fulla Y, Westerterp K R, Richalet J-P.
Comparative response of EPO and soluble transferrin
receptor at high altitude. Med Sci Sports Exerc
36:1493-1498, 2004
Woorons X, Mollard P, Lamberto C, Letournel M, Richalet
J-P. Effect of acute hypoxia on maximal exercise in
trained and sedentary women. Med Sci Sports Exerc
37 : 147-154, 2005
Richalet J-P, Gratadour P, Robach P, Pham I, Déchaux M, Joncquiert-Latarjet
A, Mollard
P, Brugniaux
J, Cornolo
J. Sildenafil
inhibits the altitude-induced hypoxemia and pulmonary
hypertension. Am J Respir Crit Care Med 171: 275-281,
2005
Tiollier E, Schmitt L, Burnat P, Fouillot J-P, Robach P,
Filaire E, Guezennec CY, Richalet J-P. “Living High
–Training Low ” altitude training: effects on
mucosal immunity. Eur J Appl Physiol 94:298-304. 2005
Leon-Velarde F, Maggiorini M, Reeves JT, Aldashev A,
Asmus I, Bernardi L, Ge RL,Hackett P, Kobayashi T, Moore
LG, Penaloza D, Richalet JP, Roach R, Wu T, Vargas E,
Zubieta-Castillo G, Zubieta-Calleja G. Consensus
statement on chronic and subacute high altitude diseases.
High Alt Med Biol. 6:147-157, 2005.
Povea C, Schmitt L, Brugniaux J, Nicolet G, Richalet J-P,
Fouillot J-P. Effects of Intermittent Hypoxia on Heart
Rate Variability during Rest and Exercise. High Alt Med
Biol 6:215-225, 2005
Roels B, Schmitt L, Libicz S, Bentley D.J, Richalet J-P
and Millet G.P. Specificity of VO2max and the ventilatory
threshold in free swimming and cycle ergometry:
comparison between triathletes and swimmers. Brit J of
Sports Med 39:965-968, 2005
Morel OE, Aubert R, Richalet J-P, Chapelot D. Simulated
high altitude selectively decreases protein intake and
lean mass gain in rats. Physiology & Behavior
86:145-153, 2005
Cornolo J, Brugniaux JV, Macarlupu JL, Privat C,
León-Velarde F and Richalet J-P. Autonomic adaptations in
Andean trained participants to a 4,220m altitude
marathon. Med Sci Sports Exerc. 37:2148-2153, 2005
Richalet J-P, Rivera M, Bouchet P, Chirinos E, Onnen I,
Petitjean O, Bienvenu A, Lasne F, Moutereau S and
León-Velarde F. Acetazolamide, a treatment for chronic
mountain sickness. Am J Resp Crit Care Med.
172:1427-1433, 2005
Gonzalez NC, Henderson KK, Favret F and Richalet JP. Rats
living high, training low, show polycythemia-mediated
increase in VO2max in spite of reduced tissue O2
extraction. J Appl Physiol. 99:2456, 2005
Brugniaux JV, Schmitt L, Robach P, Jeanvoine H,
Zimmermann H, Nicolet G, Duvallet A, Fouillot J-P and
Richalet J-P. Living High - Training Low: Tolerance and
acclimatization in elite endurance athletes. Eur J Appl
Physiol. 96: 66-77, 2006
Roels B, Hellard P, Schmitt L, Robach P, Richalet J-P and
G.P. Millet. Is it more effective to live and train at
1200 m than at 1850 m in term of performance and
haematological benefits in highly trained swimmers ? Brit
J Sports Med 40(2): e4, 2006
Brugniaux JV, Schmitt L, Robach P, Nicolet G, Fouillot
JP, Moutereau S, Lasne F, Pialoux V, Saas P, Chorvot MC,
Cornolo J, Olsen NV, Richalet JP. Eighteen days of
"living high, training low" stimulate erythropoiesis and
enhance aerobic performance in elite middle-distance
runners. J Appl Physiol. 100: 203-211, 2006
Favret F, Henderson KK, Richalet J-P, Gonzalez NC.
Exercise training improves lung gas exchange, attenuates
acute hypoxic pulmonary hypertension, but does not
prevent pulmonary hypertension of prolonged hypoxia. J
Appl Physiol. 100: 20-25, 2006
Macarlupu JL, Buvry A, Morel O-E, Leon-Velarde F,
Richalet J-P, Favret F. Characterisation of ventilatory
response to hypoxia in a model of transgenic anemic mice.
Respir Physiol Neurobiol. 150 : 19-26, 2006a
Macarlupú JL, Buvry A, Morel O-E, Leon-Velarde F,
Richalet J-P, Favret F. Time course of ventilatory
acclimatization to hypoxia in a model of anemic
transgenic mice. Respir Physiol Neurobiol
,
153:
14-22,
2006b
Schmitt L, Hellard P, Millet GP, Roels B, Richalet
J-P, Fouillot J-P. Heart rate variability and performance
at two different altitudes in well-trained swimmers. Int
J Sports Med 27: 226-231, 2006
Cornolo J, Fouillot J-P, Schmitt L, Povea C, Robach P,
and Richalet J-P. Interactions between exposure to
hypoxia and the training-induced autonomic adaptations in
a « live high-train low » session. Eur J Appl Physiol.
96 : 389-396, 2006
Robach P, Schmitt L, Brugniaux J, Roels B, Millet G,
Hellard P, Nicolet G, Duvallet A, Fouillot J-P, Moutereau
S, Lasne F, Pialoux V, Olsen NV and Richalet J-P. Living
high – training low: Effect on erythropoiesis and
aerobic performance in highly trained swimmers. Eur J
Appl Physiol 96: 423-433, 2006
Tual L, Morel O-E, Favret F, Guernier C, Buvry A, Germain
L, Bernaudin J-F, Richalet J-P. Carvedilol inhibits right
ventricular hypertrophy induced by chronic hypobaric
hypoxia. Pfugers Arch 452 :371-379, 2006
León-Velarde F, Richalet J-P. Respiratory Control in
Residents at High Altitude: Physiology and
Pathophysiology. High Alt Med Biol 7 :125-137, 2006
Mounier R, Fellmann N, Pialoux V, Cayre A, Schmitt L,
Richalet J-P, Robach P, Lasne F, Roels B, Millet G,
Coudert J, Clottes E. Leukocyte’s HIF-1 expression
and training-induced erythropoietic response in swimmers.
Med Sci Sports Exerc 38:1410-1417, 2006
Robach P, Schmitt L, Brugniaux JV, Nicolet G, Duvallet A,
Fouillot J-P, Pialoux V, Moutereau S, Lasne F, Olsen NV
and Richalet J-P. Living high – training low:
effect on erythropoiesis and maximal aerobic performance
in elite Nordic skiers. Eur J Appl Physiol 97:627-636,
2006
Schmitt L, Millet G, Robach P, Nicolet G, Brugniaux J,
Fouillot J-P, Richalet J-P. Influence of "Live high -
train low" on performance and economy of work in elite
endurance athletes. Eur J Appl Physiol 97: 627-636, 2006
Pialoux V, Mounier R, Ponsot E, Rock E, Mazur A, Dufour
S, Richard R,Richalet JP, Coudert J, Fellmann N. Effects
of exercise and training in hypoxia on
antioxidant/pro-oxidant balance. Eur J Clin Nutr.
60:1345-54, 2006.
Woorons X, Mollard P, Pichon A, Lamberto C, Letournel M,
Richalet J-P. Submaximal exercise in hypoxia induces a
greater arterial desaturation in trained than untrained
men. Scandinavian Journal of Medicine and Science in
Sports 17: 431-436, 2007.
Mollard P, Woorons X, Letournel M, Cornolo J, Lamberto C,
Beaudry M, Richalet JP. Role of maximal heart rate and
arterial O2 saturation on the decrement of
VO2max in moderate acute hypoxia in trained and untrained
men. Int J Sports Med.28:186-192, 2007
Richalet J-P. A proposed classification of environmental
adaptation : the example of high altitude. Reviews
Env Science Biotech 6:223-229, 2007
Trabelsi Y, Z. Tabka Z, Richalet J-P, Gharbi N, Bienvenu
A, Guenard H, Buvry
A. Spirometric Values in Tunisian children: relationship
with pubertal status. Ann Human Biol 34 :195-205,
2007
Woorons X, Mollard P, Pichon A, Duvallet A, Richalet J-P,
Lamberto C. Prolonged expiration down to residual volume
leads to severe arterial hypoxemia in athletes during
submaximal exercise. Respir Physiol Neurobiol
158 :75-82, 2007
Mollard P, Woorons X, Letournel M, Lamberto C, Favret F,
Pichon A, Beaudry M, Richalet J-P. Determinants of
maximal oxygen uptake in moderate acute hypoxia in
endurance athletes. Respir Physiol Neurobiol,
100:663-673, 2007.
Favret F, Richalet J-P. Exercise in hypoxia: the role of
the autonomous nervous system. Respir Physiol
Neurobiol
158:280-286, 2007.
Mollard P, Woorons X, Letournel M, Lamberto C, Favret F ,
Pichon A, Beaudry M and Richalet J-P. Determinant factor
of aerobic performance in moderate acute hypoxia in women
endurance athletes. Respir Physiol Neurobiol 159:178-186,
2007.
Schmitt L, Fouillot JP, Millet GP, Robach P, Nicolet G,
Brugniaux J, Richalet JP. Altitude, Heart rate
variability and aerobic capacities.Int J Sports Med.
29:300-306, 2008
El
Hasnaoui-Saadani R,
Cardenas Alayza R,
Launay T,
Pichon A,
Quidu P,
Beaudry M,
Leon-Velarde F,
Richalet JP,
Duvallet A,
Favret F. Brainstem NO modulates
ventilatory acclimatization to hypoxia in mice. J Appl
Physiol. 103:1506-1512, 2007.
Woorons X, Mollard P, Pichon A, Duvallet A, Richalet J-P,
Lamberto C. Effects of a 4-week training with voluntary
hypoventilation carried out at low pulmonary volumes.
Respir Physiol Neurobiol 160: 123-130, 2008.
Richalet JP, Chenivesse C, Larmignat P, Meille L. High
altitude pulmonary oedema, Down syndrome and obstructive
sleep apneas. High Alt Med Biol 9:179-181, 2008.
Richalet JP, Rivera M, Maignan M, Privat C, Pham I,
Macarlupu JL, Petitjean O, León-Velarde F. Acetazolamide
for Monge's disease: efficiency and tolerance. Am J
Respir Crit Care Med 177:1370-1376, 2008
Richalet JP, Gore CJ. Live and/or sleep high - train low,
using normobaric hypoxia. Scand J Med Sci Sports, 18
(Suppl 1) : 29-37, 2008
Rivera-Ch M, Huicho L, Bouchet P, Richalet JP,
León-Velarde F. Effect of acetazolamide on ventilatory
response in subjects with chronic mountain sickness.
Respir Physiol Neurobiol. 162: 184-189, 2008.
Brugniaux JV, Niva A, Pulkkinen I, Laukkanen RM, Richalet
JP, Pichon AP. Polar Activity Watch 200: a new device to
accurately assess energy expenditure. Br J Sports Med.
2008 Apr 15. [Epub ahead of print]
Mollard P, Woorons X, Antoine-Jonville S, Jutand L,
Richalet JP, Favret F, Pichon A.'Oxygen uptake efficiency
slope' in trained and untrained subjects exposed to
hypoxia. Respir Physiol Neurobiol 161:167-173, 2008.
Trabelsi Y, Pariès J, Harrabi
I, Zbidi A, Tabka Z, Richalet JP, Buvry A. Factors
affecting the development of lung function in Tunisian
children. Am J Hum Biol 20:716-725, 2008
Maignan M, Rivera-Ch M, Privat C, León-Velarde F,
Richalet J-P, Pham I. Pulmonary pressure and cardiac
function in chronic mountain sickness patients.
Chest,135:499-504, 2009
El Hasnaoui-Saadani R, Pichon A, Marchant D, Olivier P,
Launay T, Quidu P, Beaudry M, Duvallet A, Richalet JP,
Favret F. Cerebrovascular adaptation to chronic anemia in
a model of Erythropoietin deficient mice exposed to
hypoxia. Am J Physiol Regul Integr Comp Physiol
296:R801-811, 2009
Pialoux V, Mounier R, Rock E,
Mazur A, Schmitt L, Richalet JP, Robach P, Coudert J,
Fellmann N. Effects of acute hypoxic exposure on
prooxidant/antioxidant balance in elite endurance
athletes. Int J Sports Med 30:87-93, 2009.
Marcora SM,
Kayser B, Amann M, Lundby C, Wagner PD, Nybo L, Grassi B,
Perrey S, van Lieshout JJ, Marino FE, Brooks GA, Richalet
JP. Commentaries on Viewpoint: Evidence that reduced
skeletal muscle recruitment explains the lactate paradox
during exercise at high altitude. J Appl Physiol
106:739-744, 2009.
Pialoux V, Mounier R, Rock E,
Mazur E, Schmitt L, Richalet JP, Robach P, Brugniaux J,
Coudert J, Fellmann N. Effects of the « Live High
– Train Low » method on
pro-oxidant/antioxydant balance on elite athletes. Eur J
Clin Nutr 63:756-762, 2009
Bourdillon N, Mollard P,
Letournel M, Beaudry M, Richalet JP. Non-invasive
evaluation of the capillary recruitment in the human
muscle during exercise in hypoxia. Respir Physiol
Neurobiol 165:237-244, 2009
Pialoux V., Mounier R., Brugniaux J., Rock E., Mazur A.,
Richalet J.P., Robach P., Coudert J., and Fellmann
N.Thirteen days of "live high - train low" does not
affect prooxidant/antioxidant balance in elite swimmers.
Eur J Appl Physiol 106:517-524, 2009.
Pialoux V, Brugniaux JV, Fellmann N, Richalet JP, Robach
P, Schmitt L, Coudert J, Mounier R. Oxidative stress and
HIF-1a modulate hypoxic ventilatory responses after
hypoxic training on athletes. Respir Physiol Neurobiol
167:217-220, 2009
Richalet JP, Gimenez-Roqueplo AP, Peyrard S, Vénisse A,
Marelle L, Burnichon N, Bouzamondo A, Jeunemaitre X,
Azizi M, Elghozi JL. A role for succinate deshydrogenase
genes in low chemoresponsiveness to hypoxia ? Clin Auton
Res 19:335-342, 2009
Pichon A, Zhenzhong B, Favret F, Jin G, Shufeng H,
Marchant D, Richalet JP, Ge RL. Long-term ventilatory
adaptation and ventilatory response to hypoxia in plateau
pika (Ochotona curzoniae): role of nNOS and dopamine. Am
J Physiol Regul Integr Comp Physiol 297: R978
–R987, 2009
Bourdillon N, Mollard P, Letournel M, Beaudry M, Richalet
JP. Interaction between hypoxia and training on NIRS
signal during exercise: contribution of a mathematical
model. Respir Physiol Neurobiol 169:50-61, 2009
Mounier R, Pialoux V, Schmitt L, Richalet JP, Robach P,
Coudert J, Clottes E, Fellmann N. Effects of acute
hypoxia tests on blood markers in high-level endurance
athletes. Eur J Appl Physiol.106:713-720, 2009
Charlot K, Cornolo J, Brugniaux JV, Richalet JP, Pichon
A. Interchangeability between heart rate and
photoplethysmography variabilities during sympathetic
stimulations. Physiol Meas 30: 1357-1369, 2009
Pham I, Wuerzner G, Richalet JP, Peyrard S, Azizi M.
Endothelin receptors blockade blunts hypoxia-induced
increase in PAP in humans. Eur J Clin Invest 40 :
195-202, 2010
Launay T, Hagström L, Marchant D, Lottin-Divoux S, Quidu
P, Favret F, Duvallet A, Darribère T, Richalet JP,
Beaudry M. Blunting effect of hypoxia on the
proliferation and differentiation of human primary and
rat L6 myoblasts not counteracted by Epo. Cell prolif
43 : 1-8, 2010
Hagström L, Canon F, Agbulut O, Marchant D, Serrurier B,
Richalet JP, Beaudry M, Bigard X and Launay T. Skeletal
muscle intrinsic functional properties are preserved in a
model of erythropoietin deficient mice exposed to
hypoxia. Pflügers Archiv 459: 713-723, 2010
Pialoux V, Brugniaux JV, Rock E, Mazur A, Schmitt L,
Richalet JP, Robach P, Clottes E, Coudert J, Fellmann N,
Mounier R. Antioxidant status of elite athletes remains
impaired 2 weeks after a simulated altitude training
camp. Eur J Nutr. 49(5):285-92, 2010
Brugniaux JV, Niva A, Pulkkinen I, Laukkanen RM, Richalet
JP, Pichon AP. Polar Activity Watch 200: a new device to
accurately assess energy expenditure. Br J Sports Med.
44:245-249, 2010.
Hagström L, Agbulut O, El-Hasnaoui-Saadani R, Marchant D,
Favret F, Richalet JP, Beaudry M, Launay T. Epo is
relevant neither for microvascular formation nor for the
new formation and maintenance of mice skeletal muscle
fibres in both normoxia and hypoxia. J Biomed Biotechnol.
2010 (Epub 2010 Apr 14)
Mollard P, Bourdillon N, Letournel M, Herman H, Gibert S,
Pichon A, Woorons X, Richalet JP. Validity of
arterialized earlobe blood gases at rest and exercise in
normoxia and hypoxia. Respir Physiol Neurobiol.
172:179-83, 2010
Woorons X, Bourdillon N, Vandewalle H, Lamberto C,
Mollard P, Richalet JP, Pichon A. Exercise with
hypoventilation induces lower muscle oxygenation and
higher blood lactate concentration: role of hypoxia and
hypercapnia. Eur J Appl Physiol. 110:367-77, 2010
Richalet JP, Letournel M, Souberbielle JC. Effects of
high altitude hypoxia on the hormonal response to
hypothalamic factors. Am J Physiol Regul Integr Comp
Physiol. 299:R1685-92, 2010
Bourguignon M, Yaghi L, Flajollet S, Radanne-Krawice I,
Rouas-Freiss N, Lugrin D, Richalet JP, Carosella ED,
Moreau P. Increased soluble human leukocyte antigen-G
levels in peripheral blood from climbers on Mount
Everest. Hum Immunol. 71:1105-1108, 2010.
Richalet JP, Letournel M, Salama J. Holmes-Addie syndrome
associated with High Altitude Pulmonary Edema and low
chemoresponsiveness to hypoxia. Clin Auton Res.
21 :55-56, 2011.
Woroons X, Bourdillon N, Lamberto C, Vandewalle H,
Richalet JP, Mollard P, Pichon A. Cardiovascular
responses during hypoventilation at exercise. Int J
Sports Med 32 :438-445, 2011
Richalet JP, Larmignat P, Poitrine E, Letournel M,
Canouï-Poitrine F. Physiological risk factors of severe
high altitude illness: a prospective cohort study. Am J
Resp Crit Care Med. 2011 (in press)
Pham I, Wuerzner G, Richalet JP, Peyrard S, Azizi M.
Bosentan effects in hypoxic pulmonary
vasoconstriction : preliminary study in subjects
with or without high altitude edema history. Pulm. Circ,
2012 (in press)
Lhuissier F, Brumm M, Ramier D, Richalet JP. Ventilatory and
cardiac responses to hypoxia at submaximal exercise are
independent of altitude and exercise intensity. J. Appl.
Physiol. 2012
Revues générales
Richalet J.-P. Aptitude
cardio-vasculaire à l’altitude. In «Cardiologie du
sport», Masson éd., 2000, pp 195-199
Dumas
J.-L., Richalet J.-P., Lamberto C., Petitjean A.
100 Q.C.M. corrigés d’anatomie et de
physiologie. Maloine éd., Paris, 2000
Richalet J-P. The Endocrine
System. In: "High altitude. An Exporation of Human
Adaptation". Lung Biology in Health and Disease. C.
Lenfant Series, Vol 161. T.F. Hornbein and R.B. Schoene
eds, Marcel Dekker Inc. New York. p 601-644, 2001
Richalet J.-P., Larmignat P. Pathologie liée à la haute
altitude. In : « Réanimation Médicale ». Sous
la direction de J.-M. Boles et coll., Masson éd. 2001, p
1573-1576
Richalet J.-P. Alimentation et environnement –
Altitude. In: « Apports nutritionnels conseillés
pour la population française », 3ème éd. Tec & Doc, Paris, 2001,
p 388-390.
Richalet J.-P., Larmignat P.
Les pathologies d’altitude. In :
« Urgences médico-chirurgicales de
l’adulte ». Sous la direction de P. Carli et
B. Riou. Arnette éd., Paris, 2003, p 800-805.
Richalet J.-P. Mal aigu des montagnes et complications.
In : « Anesthésie réanimation
chirurgicale ». Sous la direction de K. Samii.
Flammarion éd., Paris, 2003, p 1176-1180.
Richalet J.-P., Herry J.-P.
Médecine de l’alpinisme et des sports de montagne,
Masson éd. (3ème édition), 2003
Richalet J.-P., Herry J.-P. Médecine de l’alpinisme
et des sports de montagne, Masson éd.
(4ème
édition), 2006
Richalet J.-P., Larmignat P. Pathologie liée à la haute
altitude. In : « Réanimation Médicale ». Sous
la direction de J.-M. Boles et coll., Masson éd. 2007,
2ème
éd
Richalet J-P. Mal aigu des montagnes et ses
complications, prevention, preparation à un séjour en
montagne. In “ Médecine du sport pour le
praticien”. P. Rochcongar et H Monod, Elsevier
Masson ed., Paris 2009, chapitre 14.
Richalet JP. Altitude, hypoxia
and exercise. In Exercise physiology : from a
cellular to an integrative approach. P. Connes, O. Hue
and S. Perrey eds. IOS press, 2010
Richalet JP. Altitude, exercise and training. In
« Encyclopedia of exercise medicine in health and
disease » Springer-Verlag, 2010
Richalet JP. Hypertension artérielle pulmonaire et
altitude. In « Hypertension artérielle
pulmonaire » dir. G. Simonneau. Med-line éd. 2010
Richalet J-P. The Endocrine
System. In: "High altitude. An Exporation of Human
Adaptation". Lung Biology in Health and Disease. E
Swenson and P Bärtsch eds, in press, 2012